Welcome to CPAAN

The CPAAN team is dedicated to unraveling the complexities of Alzheimer's Disease through cutting-edge cognitive data analysis. Our team of experts brings together a wealth of knowledge in neuroscience, data science, and healthcare to address one of the most pressing challenges of our time.


Paul Crane, MD MPH

Dr. Paul K. Crane is a general internist based at Harborview Medical Center in Seattle, WA, and Professor of Medicine at the University of Washington School of Medicine. He serves as multiple principal investigator of the Adult Changes in Thought study (ACT), a prospective cohort study of older adults who are members of Kaiser Permanente Washington.


Dr. Crane has particular expertise in psychometrics and cognition. Psychometrics is the statistical approach to testing data. He also leads the Cognitive Harmonization Core for the Alzheimer’s Disease Sequencing Project’s Phenotype Harmonization Consortium (ADSP-PHC), and served a similar role for the Artificial Intelligence for Alzheimer’s Disease (AI4AD) initiative.


The Center for Psychometric Analyses in Aging and Neurodegeneration (CPAAN) has harmonized and co-calibrated composite scores for memory, executive functioning, language, and visuospatial from over 300,000 visits for over 100,000 unique research participants across many of the major studies of older adults and Alzheimer’s disease in the US and around the world, including studies in English, Dutch, Spanish, and Korean.


Dr. Crane and his team are especially interested in subgrouping Alzheimer’s disease. Perhaps AD should be considered a group of conditions rather than a single thing. The CPAAN team, along with their colleagues, have developed an approach using relative impairments across cognitive domains at the time of AD diagnosis. Using this approach, they have found distinctions across subgroups with respect to genetic associations, clinical findings, and neuroimaging. Current work in ACT as Project 2 focuses on imaging, neuropathology, and the lived experiences of people with AD dementia.


The CPAAN

Team

Seo-Eun Choi, PhD

Jeanne Galleé, PhD CCC-SLP

Laura Gibbons, PhD

Brandon Klinedinst, PhD MS

Michael Lee, PhD MPH

Shubhabrata ("Joey") Mukherjee, PhD MS

Connie Nakano, MPH

Phoebe Scollard, MA

Taiki Sugimoto, PhD

Publications

Refereed Journals


1. Crane PK, Gibbons LE, Jolley L, van Belle G. Differential item functioning analysis with ordinal logistic regression techniques. DIFdetect and difwithpar. Medical Care 2006; 44(11 supp 3): S115-S123. PMID: 17060818


2. Crane PK, Hart DL, Gibbons LE, Cook KF. A 37-item shoulder functional status item pool had negligible differential item functioning. Journal of Clinical Epidemiology 2006; 59: 478-484. PMID: 16632136


3. Crane PK, Gibbons LE, Jolley L, van Belle G, Selleri R, Dalmonte E, De Ronchi D. Differential item functioning related to education and age in the Italian version of the Mini-Mental State Examination. International Psychogeriatrics 2006; 18: 505-515. PMID: 16478571


4. Crane PK, Gibbons LE, Narasimhalu K, Lai JS, Cella D. Rapid detection of differential item functioning in assessments of health-related quality of life: the Functional Assessment of Cancer Therapy. Quality of Life Research 2007; 16: 101-114. PMID: 17111233


5. Teresi JA, Ocepek-Welikson K, Kleinman M, Cook KF, Crane PK, Gibbons LE, Morales LS, Orlando-Edelen M, Cella D. Evaluating measurement equivalence using the item response theory log-likelihood ratio (IRTLR) method to assess differential item functioning (DIF): applications (with illustrations) to measures of physical functioning ability and general distress. Quality of Life Research 2007; 16 Suppl 1: 43-68. PMID: 17484039


6. Crane PK, Gibbons LE, Ocepek-Welikson K, Cook K, Cella D, Narasimhalu K, Hays RD, Teresi JA. A comparison of three sets of criteria for determining the presence of differential item functioning using ordinal logistic regression. Quality of Life Research 2007; 16 Suppl 1: 69-84. PMID: 17554640


7. Cook KF, Teal CR, Bjorner JB, Cella D, Chang CH, Crane PK, Gibbons LE, Hays RD, McHorney CA, Ocepek-Welikson K, Raczek AE, Teresi JA, Reeve BB. IRT Health Outcomes Data Analysis Project: An Overview and Summary. Quality of Life Research 2007;16 Suppl 1: 121-132. PMID: 17351824


8. * Crane PK, Narasimhalu K, Gibbons LE, Mungas DM, Haneuse S, Larson EB, Kuller L, Hall K, van Belle G. Item response theory facilitated cocalibrating cognitive tests and reduced bias in estimated rates of decline. Journal of Clinical Epidemiology 2008; 61: 1018-1027; 1027e1-1027e9. PMCID: PMC2762121


9. Crane PK, Narasimhalu K, Gibbons LE, Pedraza O, Mehta KM, Tang Y, Manly JJ, Reed BR, Mungas DM. Composite scores for executive function items: demographic heterogeneity and relationships with quantitative magnetic resonance imaging. Journal of the International Neuropsychological Society 2008; 14: 746-759. PMCID: PMC2683684


10. Gibbons LE, McCurry S, Rhoads K, Masaki K, White L, Borenstein AR, Larson EB, Crane PK. Japanese-English language equivalence of the Cognitive Abilities Screening Instrument among Japanese-Americans. International Psychogeriatrics 2009; 21: 129-137. PMCID: PMC2746009


11. Crane PK, Gibbons LE, Arani K, Nguyen V, Rhoads K, McCurry SM, Launer L, Masaki K, White L. Midlife use of written Japanese and protection from late life dementia. Epidemiology 2009; 20: 766-774. PMCID: PMC3044600


12. Crane PK, Gibbons LE, Willig JH, Mugavero MJ, Lawrence ST, Schumacher JE, Saag MS, Kitahata MM, Crane HM. Measuring depression levels in HIV-infected patients as part of routine clinical care using the nine-item Patient Health Questionnaire (PHQ-9). AIDS Care 2010; 22(7): 874-885. PMCID: PMC3410748


13. Crane PK, Gruhl JC, Erosheva EA, Gibbons LE, McCurry SM, Rhoads K, Nguyen V, Arani K, Masaki K, White L. Use of spoken and written Japanese did not protect Japanese-American men from cognitive decline in late life. Journals of Gerontology Series B: Psychological Sciences 2010; 65(6): 654-66. PMID: 20639282; PMCID: PMC2954325


14. Gates GA, Gibbons LE, McCurry SM, Crane PK, Feeney MP, Larson EB. Executive dysfunction and presbycusis in older persons with and without memory loss and dementia. Cognitive and Behavioral Neurology 2010; 23(4): 218-223. PMCID: PMC3058598


15. Gibbons LE, Crane PK, Mehta KM, Pedraza O, Tang Y, Manly JJ, Narasimhalu K, Teresi J, Jones RN, Mungas D. Multiple, correlated covariates associated with differential item functioning (DIF): Accounting for language DIF when education levels differ across languages. Ageing Research 2011; 2(1):19-25. PMID: 22900138. PMCID: PMC3418868


16. Choi SW, Gibbons LE, Crane PK. lordif: an R package for detecting differential item functioning using iterative hybrid ordinal logistic regression / item response theory and Monte Carlo simulations. Journal of Statistical Software 2011; 39(8):1-30. PMID: 21572908. PMCID: PMC3093114


17. Gibbons LE, Crane HM, Feldman B, Mugavero M, Willig JH, Patrick D, Schumacher J, Saag M, Kitahata MM, Crane PK. Migrating from a legacy fixed-format measure to CAT administration: calibrating the PHQ-9 to the PROMIS depression measures. Quality of Life Research 2011; 20(9):1349-1357. PMCID: PMC3175024. Erratum in Quality of Life Research 2013; 22(2): 459-460.


18. Skinner J, Carvalho JO, Potter GG, Thames A, Zelinski E, Crane PK, Gibbons LE; Alzheimer’s Disease Neuroimaging Initiative. The Alzheimer’s Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): An expansion of the ADAS-Cog to improve responsiveness in MCI. Brain Imaging and Behavior 2012; 6(4): 489-501. PMID: 22614326. PMCID:PMC3873823.


19. *Crane PK, Carle A, Gibbons LE, Insel P, Mackin RS, Gross A, Jones RN, Mukherjee S, Curtis SM, Harvey D, Weiner M, Mungas D; Alzheimer’s Disease Neuroimaging Initiative. Development and assessment of a composite score for memory in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Brain Imaging and Behavior 2012; 6(4): 502-516. PMID: 33783395. PMCID: PMC3806057


20. Gibbons LE, Carle AC, Mackin RS, Harvey D, Mukherjee S, Insel P, Curtis SM, Mungas D, Crane PK; Alzheimer’s Disease Neuroimaging Initiative. A composite score for executive functioning, validated in Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging and Behavior 2012; 6(4): 517-527. PMID: 22644789. PMCID: PMC3684181.


21. *Mukherjee S, Kim S, Gibbons LE, Nho K, Risacher S, Glymour MM, Habeck C, Lee GJ, Mormino E, Ertekin-Taner N, Montine TJ, DeCarli C, Saykin AJ, Crane PK; Alzheimer’s Disease Neuroimaging Initiative. Genetic architecture of resilience of executive functioning. Brain Imaging and Behavior 2012; 6(4): 621-633. PMID: 22711244. PMCID: PMC3607298


22. Nho K, Risacher SL, Crane PK, DeCarli C, Glymour MM, Habeck C, Kim S, Lee GJ, Mormino E, Mukherjee S, Shen L, West JD, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer’s disease. Brain Imaging and Behavior 2012; 6(4): 551-567. PMID: 23070747. PMCID: PMC3532574


23. Mukherjee S, Gibbons LE, Kristjansson E, Crane PK. Extension of an iterative hybrid ordinal logistic regression/item response theory approach to detect and account for differential item functioning in longitudinal data. Psychological Test and Assessment Modeling 2013; 55(2): 127-147. PMID: 24432199. PMCID: PMC3890358.


24. Dams-O’Connor K, Gibbons LE, Bowen JD, McCurry SM, Larson EB, Crane PK. Risk for late-life re-injury, dementia and death among individuals with traumatic Brain Injury: a population-based study. Journal of Neurology, Neurosurgery, and Psychiatry 2013; 84(2): 177-182. PMD: 23172868. PMCID: PMC3752841


25. Mukherjee S, Trittschuh E, Gibbons LE, Mackin RS, Saykin A, Crane PK; Alzheimer’s Disease Neuroimaging Initiative. Dysexecutive and amnesic AD subtypes defined by single indicator and modern psychometric approaches: relationships with SNPs in ADNI. Brain Imaging and Behavior 2012; 6(4): 649-660. PMID: 23161456. PMCID: PMC3532526


26. Mungas D, Crane PK, Gibbons LE, Manly JJ, Glymour MM, Jones RN. Advanced psychometric analysis and the Alzheimer’s Disease Neuroimaging Initiative: Reports from the 2011 Friday Harbor conference. Brain Imaging and Behavior 2012; 6(4): 485-488. PMID: 23232798. PMCID: PMC3532555


27. Mukherjee S, Kim S, Ramanan VK, Gibbons LE, Nho K, Glymour MM, Ertekin-Taner N, Montine TJ, Saykin AJ, Crane PK, for the Alzheimer’s Disease Neuroimaging Initiative. Gene-based GWAS and biological pathway analysis of the resilience of executive functioning. Brain Imaging and Behavior 2014; 8 (1): 110–8. PMID: 24072271. PMCID: PMC3944472.


28. Sun X, Lu Q, Mukherjee S, Crane P, Elston R, Ritchie MD. Analysis pipeline for the epistasis search – statistical versus biological filtering. Frontiers in Genetics Front Genet. 2014 Apr 30;5:106. doi: 10.3389/fgene.2014.00106. eCollection 2014. PMID: 24817878. PMCID: PMC4012196.


29. Gross AL, Mungas DM, Crane PK, Gibbons LE, MacKay-Brandt A, Manly JJ, Muherjee S, Romero H, Sachs B, Thomas M, Potter GG, Jones RN. Effects of education and race on cognitive decline: An integrative study of generalizability versus study-specific results. Psychology and Aging 2015 Dec; 30(4): 863–80. PMID 26523693. PMCID: PMC4679562.


30. Fredericksen RJ, Edwards TC, Merlin JS, Gibbons LE, Rao D, Batey DS, Dant L, Páez E, Church A, Crane PK, Crane HM, Patrick DL. Patient and provider priorities for self-reported domains of HIV clinical care. AIDS Care 2015; 27: 1255–64. PMID: 26304263. PMCID: PMC 4643852.


31. Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE, Alzheimer’s Disease Genetics Consortium, GERAD1 Consortium, EPIC-InterACT Consortium, Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA. Associations between potentially modifiable risk factors and Alzheimer’s disease: A Mendelian randomization study. PLoS Medicine 2015 Jun 16; 12(6);e1001841; discussion e1001841. eCollection 2015 Jun. PMID: 26079503. PMCID: PMC4469461.


32. Dams-O’Connor K, Gibbons LE, Landau A, Larson EB, Crane PK. Health problems precede traumatic Brain Injury in older adults. Journal of the American Geriatrics Society 2016 April; 64 (4): 844–8. PMID: 26925541. PMCID: PMC5021441.


33. Ebbert M, Boehme KL, Wadsworth ME, Staley LA, Alzhimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Consortium, Mukherjee S, Crane PK, Ridge PG, Kauwe JS. Interaction between variants in CLU and MS4A4E modulates Alzheimer’s disease risk. Alzheimer’s & Dementia 2016 February; 12(2): 121–9. PMID: 26449541. PMCID: PMC4744542.


34. Crane PK, Gibbons LE, McCurry SM, McCormick W, Bowen JD, Sonnen J, Keene CD, Grabowski T, Montine TJ, Larson EB. Importance of home study visit capacity in dementia studies. Alzheimer’s & Dementia 2016 April; 12(4): 419–26. PMID: 2660628. PMCID: PMC4841701.


35. Crane PK, Gibbons LE, Dams-O’Connor K, Trittschuh E, Leverenz JB, Keene CD, Sonnen J, Montine TJ, Bennett DA, Leurgans S, Schneider JA, Larson EB. Association of traumatic Brain Injury with late-life neurodegenerative conditions and neuropathologic findings. JAMA Neurology 2016; 73(9): 1062-9. PMID: 27400367. PMCID: PMC5319642.


36. Mez J, Mukherjee S, Thornton T, Fardo DW, Trittschuh E, Sutti S, Sherva R, Kauwe JS, Naj AC, Beecham GW, Gross A, Saykin AJ, Green RC, Crane PK, for Executive Prominent Alzheimer’s Disease: Genetics and Risk Factors (EPAD:GRF), the Alzheimer’s Disease Neuroimaging Initiative (ADNI1), and the Alzheimer’s Disease Genetics Consortium (ADGC). The executive prominent / memory prominent spectrum in Alzheimer’s disease is highly heritable. Neurobiology of Aging 2016 May; 41:115–21. PMID: 27103524. PMCID: PMC4843522.


37. Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LAD, Pericak-Vance M, Schellenberg GD, Kauwe SK, for the Alzheimer’s Disease Genetics Consortium. Assessment of the genetic variance of late-onset Alzheimer’s disease. Neurobiology of Aging. 2016 May;41:200.e13-20. doi: 10.1016/j.neurobiolaging.2016.02.024. Epub 2016 Mar 3. PMID: 27036079. PMCID: PMC4948179.


38. Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B, Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues J-F, Berr C, Amouyel P, Bennett DA, van Duijn C, DeStefano A, Launer LJ, Ikram A, Crane PK, Lambert J-C, Mayeux R, Seshadri S, for the International Genomics of Alzheimer’s Project. Evaluation of a genetic risk score to improve risk prediction for Alzheimer's disease. Journal of Alzheimer’s Disease. 2016; 53:921–32. PMID: 27340842. PMCID: PMC5036102.


39. Crane PK, Walker RL, Sonnen J, Gibbons LE, Melrose R, Hassenstab J, Keene CD, Postupna N, Montine TJ, Larson EB. Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes. Neurobiology of Aging. 2016 Dec; 48: 72–82. PMID: 27644076. PMCID: PMC5441884.


40. Zahodne LB, Gilsanz P, Glymour MM, Gibbons LE, Brewster P, Hamilton J, Mez J, Marden JR, Nho K, Larson EB, Crane PK, Gross AL. Comparing variability, severity, and persistence of depressive symptoms as predictors of future stroke risk. American Journal of Geriatric Psychiatry. 2017 Feb; 25(2):120–128. PMID: 27866734. PMCID: PMC5253243.


41. Fardo DW, Gibbons LE, Mukherjee S, Glymour MM, McCormick W, McCurry SM, Bowen JD, Larson EB, Crane PK. Impact of home visit capacity on genetic association studies of late-onset Alzheimer’s disease. Alzheimer’s & Dementia. 2017 Aug; 13(8): 933–939. PMID: 28222301. PMCID: PMC5554082.


42. Steele NZ, Carr J, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe J, Kramer JH, Miller BL, Coppola G, Hollanbach JA, Yokoyama JS, for the Alzheimer’s Disease Neuroimaging Initiative. Fine-mapping of the human leukocyte antigen (HLA) locus as a risk factor for Alzheimer’s disease: a case-control study. PLoS Medicine. 2017 Mar 28; 14(3):21002272. Doi: 10.1371/journal.pmed.1002272. eCollectioni 2017 Mar. PMID: 28350795. PMCID: PMC5369701.


43. Gibbons LE, Fredericksen R, Batey DS, Dant L, Edwards TC, Mayer KH, Mathews WC, Morales LS, Mugavero MJ, Yang FM, Paez E, Kitahata MM, Patrick DL, Crane HM, Crane PK, for the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS). Validity assessment of the PROMIS Fatigue domain among people living with HIV. AIDS Research and Therapy. 2017 Apr 11; 14L21. DOI 10.1186/s12981-017-0146-y. eCollection 2017. PMID: 28400850. PMCID: PMC5387298.


44. Crane PK, Trittschuh E, Mukherjee S, Saykin AJ, Sanders RE, Larson EB, McCurry SM, McCormick W, Bowen JD, Grabowski T, Moore M, Bauman J, Gross AL, Keene CD, Bird TD, Gibbons LE, Mez J, for the Executive Prominent Alzheimer’s Disease: Genetics and Risk Factors (EPAD:GRF) Investigators. Incidence of cognitively-defined late-onset Alzheimer’s dementia subgroups from a prospective cohort study. Alzheimer’s & Dementia. 2017 Dec; 13(12): 1307–1316. PMID: 2862377. PMCID: PMC5723557.


45. Fredericksen RJ, Gibbons L, Brown S, Edwards TC, Yang FM, Fitzsimmons E, Alperovitz-Bichell K, Godfrey M, Wang A, Church A, Gutierrez C, Paez E, Dant L, Loo S, Walcott M, Mugavero MJ, Mayer K, Mathews WC,Patrick DL, Crane PK, Crane HM. Medication understanding among patients living with multiple chronic conditions: implications for patient-reported measures of adherence. Research in Social and Administrative Pharmacy. 2017 Jun 20 [Epub ahead of print]. PMID: 28651924. PMCID: PMC5738290.


46. Lu Q, Powles RL, Abdallah S, Ou D, Wang Q, Hu Y, Lu Y, Liu W, Mukherjee S, Crane PK, Zhao H. Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease. PLoS Genetics. 2017 Jul 24; 13(7):e1006933. eCollection 207 Jul. PMID: 28742084. PMCID: PMC5546707.


47. Li G, Larson EB, Shofer JB, Crane PK, Gibbons LE, McCormick W, Bowen JD, Thompson ML. Cognitive trajectory changes over 20 years before dementia diagnosis: a large cohort study. Journal of the American Geriatrics Society. 2017 Decl 65(12): 2627–2633. PMID: 28940184. PMCID: PMC5729097.


48. Mez J, Marden JR, Mukherjee S, Walter S, Gibbons LE, Gross AL, Zahodne LB, Gilsanz P, Brewseter P, Nho K, Crane PK, Larson EB, Glymour M. Alzheimer’s disease genetic risk variants beyond APOE 4 predict mortality. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 2017 Aug 14; 8: 188–195. eCollection 2017. PMID: 2893503. PMCID: PMC5604953.


49. Miller JA, Guillozet-Bongaarts A, Gibbons LE, Postupna N, Renz A, Beller AE, Sunkin SM, Ng L, Rose SE, Smith KA, Szafer A, Barber C, Bertagnolli D, Bickley K, Brouner K, Caldejon S, Chapin M, Chua ML, Coleman NM, Cudaback E, Cuhaciyan C, Dalley RA, Dee N, Desta T, Dolbeare TA, Dotson N, Fisher M, Gaudrealt N, Gee G, Gilbert TL, Goldy J, Griffin F, Habel C, Haradon Z, Hejazinia N, Hellstern LL, Howard K, Howard R, Johal J, Jorstad NL,Josephsen SR, Kurn CL, Lai F, Lee E, Lee F, Lemon T, Li X, Marshall DA, Melchor J, Mukherjee S, Nyhus J, Pendergraft J, Potekhina L, Rha EY, Rice S, Rosen D, Sapru A, Schantz A, Shen E, Sherfield E, Shi S, Sodt AJ, Thatra N, Tieu M, Walker R, Wilson AM, Montine TJ, Larson EB, Bernard A, Crane PK, Ellenbogen RG, Keene CD, Lein E. Neuropathological and transcriptomic characteristics of the aged brain. eLife. 2017 Nov 9;6. pii: e31126. doi: 10.7554/eLife.31126. PMID: 29120328 PMCID: PMC5679757.


50. Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Gifford K, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Bennett DA, Schneider JA, Jefferson AL for the Alzheimer’s for the Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative. Sex-specific association of Apolipoprotein E on cerebrospinal fluid levels of tau. JAMA Neurology. 2018 Aug 1;75(8):989–998. doi: 10.1001/jamaneurol.2018.0821. PMID: 29801024 PMCID: PMC6142927.


51. Fredericksen RJ. Mayer KH. Gibbons LE. Edwards TC. Yang F. Walcott M. Brown S. Dant L. Loo S. Gutierrez C. Paez E. Fitzsimmons E. Wu AW. Mugavero MJ. Mathews WC. Lober WB. Kitahata MM. Patrick DL. Crane PK. Crane HM. Development and content validation of a patient-reported sexual risk measure for use in primary care. Journal of General Internal Medicine. 2018 May 29. doi: 10.1007/s11606-018-4496-5. [Epub ahead of print] PMID: 29845470 PMCID: PMC6153230.


52. Lee CS, Larson EB, Gibbons LE, Lee AY, McCurry SM, Bowen JD, McCormick WC, Crane PK. Associations between recent and established ophthalmic conditions and risk of Alzheimer’s disease. Alzheimer’s & Dementia. 2018 Aug 2. pii: S1552-5260(18)33034–6. doi: 10.1016/j.jalz.2018.06.2856. [Epub ahead of print]. PMID: 30098888. PMCID: Pending.


53. Deming Y*, Dumitrescu L*, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chinik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, for the Alzheimer’s Disease Neuroimaging Intiative (ADNI), for the Alzheimer’s Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C‡, Hohman TJ‡. Sex-specific genetic predictors of Alzheimer’s disease biomarkers. Acta Neuropathologica. 2018 Dec;136(6):857-872. doi: 10.1007/s00401-018-1881-4. PMID: 29967939 PMCID: PMC6280657.


54. Fredericksen RJ, Yang FM, Gibbons LE, Edwards TC, Brown S, Fitzsimmons E, Alperovitz-Bichell K, Godfrey M, Wang A, Church A, Gutierrez C, Paez E, Dant L, Loo S, Walcott M, Mugavero MJ, Mayer KH, Mathews WC, Patrick DL, Crane PK, Crane HM. Development and content validation of an instrument assessing adherence barriers and behaviors for use in clinical care. Research in Social and Administrative Pharmacy. 2018; 15: 1168-1176. PMID: 30327183.


55. Mukherjee S, Mez J, Trittschuh E, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi S-E, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB, for the EPAD study group and investigators from ACT, ROS, MAP, ADNI, and the University of Pittsburgh ADRC, and Crane PK. Genetic data and cognitively-defined Alzheimer’s disease subgroups. Molecular Psychiatry. 2020 Nov;25(11):2942-2951. PMID: 30514930. PMCID: PMC6548676.


56. Hu Y, Li M, Lu Q, Weng H, Wang J, Zekavat SM, Yu Z, Li B, Muchnik S, Kunkle BW, Mukherjee S, Natarajan P, Naj A, Kuzma A, Zhao Y, Crane PK, Alzheimer’s Disease Genetics Consortium, Zhao H. A statistical framework for cross-tissue transcriptome-wide association analysis. Nature Genetics. 2019 Mar;51(3):568-576. doi: 10.1038/s41588-019-0345-7. Epub 2019 Feb 25. PMID: 30804563. PMCID: PMC6788740.


57. Fredericksen RJ, Walcott M, Yang FM, Gibbons LE, Fitzsimmons E, Brown S, Mayer KH, Edwards TC, Loo S, Gutierrec C, Paez E, Dant L, Mathews WC, Mugavero MJ, Patrick DL, Crane PK, Crane HM. Circumstances surrounding high-risk sexual experiences among primary care patients living with and without HIV. Journal of General Internal Medicine. 2018; 33: 2163–2170. PMID: 30251213. PMCID: PMCID: PMC6258602.


58. Lee CS, Larson EB, Gibbons LE, Latimer CS, Rose SE, Hellstern LL, Keene CD, Crane PK, the Adult Changes in Thought Study. Ophthalmology-based neuropathology risk factors: diabetic retinopathy is associated with deep microinfarcts in a community-based autopsy study. Journal of Alzheimer’s Disease. 2019;68(2):647-655. doi: 10.3233/JAD-181087. PMID: 30883356. PMCID: PMC6450649.


59. Fredericksen RJ, Fitzsimmons E, Gibbons LE, Dougherty S, Loo S, Shurbaji S, Batey DS, Avendano-Soto S, Mathews WC, Christopoulos K, Mayer KH, Mugavero MJ, Crane PK, Crane HC. Development and content validation of the multifactoral assessment of perceived social support (MAPSS), a brief, patient-reported measure of social support for use in HIV care. AIDS Care 2019; 31(sup1):1-9. PMID: 31189333. PMCID: PMC6895409.


60. Glymour MM, Gibbons LE, Gilsanz P, Gross AL, Mez J, Brewster PW, Marden J, Zahodne LB, Nho K, Hamilton J, Li G, Larson EB, Crane PK. Initiation of antidepressant medication and risk of incident stroke: using the Adult Changes in Thought cohort to address time-varying confounding. Annals of Epidemiology 2019; 35: 42-47. PMID: 31200987.


61. Bauman J, Gibbons LE, Moore M, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Glymour MM, Mez J, Saykin AJ, Dams-O'Conner K, Bennett DA, Larson EB, Crane PK, for the Executive Prominent AD (EPAD) Investigators. Associations between depression, traumatic Brain Injury, and cognitively-defined late-onset Alzheimer's disease subgroups. Journal of Alzheimer's Disease 2019; 70: 611-619. PMID: 31256124.


62. Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, for the Alzheimer’s Disease Genetics Consortium and the Alzheimer Disease Neuroimaging Initiative, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ. Sex differences in the genetic predictors of Alzheimer’s pathology. Brain 2019; 142: 2581-2589. PMID: 31497858. PMCID: PMC6736148.


63. Latimer CS, Burke BT, Llachko NF, Currey HN, Kilgore MD, Gibbons LE, Henrikson J, Darvas M, Domoto-Reilly K, Jayadev S, Grabowski TJ, Crane PK, Larson EB, Kraemer BC, Bird TD, Keene CD. Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathologica Communications 2019; 7:91. PMID: 31174609. PMCID: PMC6556006.


64. Fredericksen RJ. Fitzsimmons E. Gibbons LE. Loo S. Dougherty S. Avendano-Soto S. Gutierrez C. Shurbaji SL. Burleson SW. Christopoulos K. Poceta J. Anderson WA. Mayer KH. Mugavero MJ. Mathews WC. Crane PK. Crane HM. How do treatment priorities differ between patients in HIV care and their providers? A mixed-methods stud. AIDS & Behavior, 2020 Apr; 24(4):1170-1180. PMID: 31832854.


65. Vance E, Gonzalez MJD, Miller JB, Alzheimer’s Disease Genetics Consortium (ADGC), Staley L, Crane PK, Mukherjee S, Kauwe JSK. Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer’s disease in large cohort. Neurobiology of Aging 2020; 89:142.e9-142.e12. PMID: 32143980.


66. Milind N, Preuss C, Haber A, Ananda G, Mukherjee S, John C, Shapley S, Logsdon B, Crane PK, Carter GW. Transcriptomic stratification of late-onset Alzheimer’s cases reveals novel genetic modifiers of disease pathology. PLoS Genetics 2020 Jun 3; 16(6): e1008775. eCollection 2020 June. PMID: 32492070. PMCID: PMC7295244.


67. Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang H, Harrison T, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Moore AM, Cambronero F, Zhong X, Raghavan NS, Vardarajan B, The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Pericak-Vance MA, Farrer LA, Wang L, Cruchaga C, Schellenberg G, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Bennett DA, Schneider JA, Crane PK, Jefferson AL , Hohman TJ. Genetic variants and functional pathways associated with resilience to Alzheimer’s disease. Brain 2020 Aug 1;143(8):2561-2575. doi: 10.1093/brain/awaa209. PMID: 32844198. PMCID: PMC7447518.


68. Kobayashi LC, Gross AL, Gibbons LE, Tommet D, Sanders RE, Choi S-E, Mukherjee S, Glymour MM, Manly JJ, Berkman LF, Crane PK, Mungas DM, Jones RN. You say tomato, I say radish: can brief cognitive assessments in the US Health Retirement Study be harmonized with its International Partner Studies? Journals of Gerontology: Psychological Sciences 2020 Nov 29:gbaa205. doi: 10.1093/geronb/gbaa205. Online ahead of print. PMID: 33249448.


69. Fredericksen RJ, Gibbons LE, Fitzsimmons E, Nance RM, Schafer KR, Batey DS, Loo S, Dougherty S, Mathews WC, Christopoulos K, Mayer KH, Mugavero MJ, Kitahata MM, Crane PK, Crane HM. Impact and correlates of sub-optimal social support among patients in HIV care. AIDS Care 2021 Jan 14:1-11. doi: 10.1080/09540121.2020.1853660. PMID: 33443445.


70. Kumar RG, Jayasinghe N, Walker RL, Gibbons LE, Power MC, Larson EB, Crane PK, Dams-O’Connor K. Association of remote traumatic Brain Injury and military employment with late-life trajectories of depressive symptom severity. Journal of Affective Disorders. 2021 Feb 15;281:376-383. doi: 10.1016/j.jad.2020.12.003. PMID: 33348181.


71. Choi SE, Mukherjee S, Gibbons LE, Sanders RE, Jones RN, Tommet D, Mez J, Trittschuh EH, Saykin A, Lamar M, Rabin L, Foldi NS, Sikkes S, Jutten RJ, Grandoit E, Mac Donald C, Risacher S, Groot C, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative, Crane PK. Development and validation of language and visuospatial composite scores in ADNI. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2020 Dec 5;6(1):e12072. doi: 10.1002/trc2.12072. eCollection 2020. PMID: 33313380. PMCID: PMC7718716.


72. Lee CS, Lee ML, Gibbons LE, Yanagihara RT, Blazes M, Kam JP, McCurry SM, Bowen JD, McCormick WC, Lee AY, Larson EB*, Crane PK*. Association between retinal artery/vein occlusions and risk of vascular dementia. Journal of Alzheimer’s Disease 2021 Mar 15. Doi: 10.3233/JAD-201492. Online ahead of print. PMID: 33749651.


73. Postupna NO, Rose SE, Gibbons LE, Coleman NM, Hellstern LL, Ritchie K, Wilson WM, Cudaback E, Li X, Melief EJ, Beller AE, Miller J, Nolan AL, Marshall DA, Walker R, Montine TJ, Larson EB, Crane PK, Ellenbogen RG, Lein ES, Dams-O'Connor K,* Keene CD.* The delayed neuropathological consequences of traumatic Brain Injury in a community-based sample. Frontiers in Neurology. 2021 Mar 16; 12:624696. PMID: 33796061. PMCID: PMC8008107.


74. Groot C, Grothe MJ, Mukherjee S, Jelistratova I, Jansen I, van Loenhoud AC, Risacher S, Saykin AJ, Mac Donald CL, Mez J, Trittschuh EH, Gryglewski G, Lanzenberger R, Pijnenburg YAL, Barkhof F, Scheltens P, van der Flier WM, Crane PK, Ossenkoppele R. Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups. NeuroImage: Clinical. 2021;30:102660. doi: 10.1016/j.nicl.2021.102660. Epub 2021 Apr 3. PMID: 33895633. PMCID: PMC8186562.


75. Groot C, Risacher SL, Chen JQA, Dicks E, Saykin AJ, Mac Donald CK, Mez J, Trittschuh E, Mukherjee S, Barkhof F, Scheltens P, van der Flier WM, Ossenkoppele R, Crane PK. Differential trajectories of hypometabolism across cognitively-defined Alzheimer’s disease subgroups. Neuroimage: Clinical. 2021 Jun 12;31:102725. doi: 10.1016/j.nicl.2021.102725. Online ahead of print. PMID: 34153688. PMCID: PMC8238088.


76. Uretzky M, Gibbons LE, Mukherjee S, Trittschuh EH, Fardo DW, Boyle PA, Keene CD, Saykin AJ, Crane PK, Schneider JA, Mez J. Longitudinal cognitive performance of Alzheimer’s disease neuropathological subtypes. Alzheimer’ & Dementia. 2021 Sep 27;7(1):e12201. doi: 10.1002/trc2.12201. eCollection 2021. PMID: 34604500. PMCID: PMC8474122.


77. Barthold D, Gibbons LE, Marcum ZA, Gray SL, Keene CD, Grabowski TJ, Postupna N, Larson EB, Crane PK. Alzheimer’s disease-related neuropathology among patients with medication treated type 2 diabetes in a community-based cohort. Journal of Alzheimer’s Disease 2021;83(3):1303-1312. doi: 10.3233/JAD-210059. PMID: 34420950.


78. Tabio L, Walker R, Crane PK, Gibbons LE, Kumar R, Power MC, Kelley AS, Lason EB, Dams-O’Connor K. Association of lifetime TBI and military employment with late-life ADL functioning: a population-based prospective cohort study. Archives of Physical Medicine and Rehabilitation 2021 Dec;102(12):2316-2324.e1. doi: 10.1016/j.apmr.2021.06.018. Epub 2021 Jul 18. PMID: 34283993


79. Mohammed A, Gibbons LE, Gates G, Anderson ML, McCurry SM, McCormick W, Bowen JD, Grabowski TJ, Crane PK*, Larson EB*. Performance on dichotic auditory tests is associated with risk for incident dementia and Alzheimer’s dementia: the Adult Changes in Thought Study. JAMA Otorhinolaryngology – Head and Neck Surgery. 2022 Jan 1;148(1):20-27. doi: 10.1001/jamaoto.2021.2716. * denotes co-senior authorship. PMID: 34647974. PMCID: PMC8517881.


80. Power MC, Murphy AE, Gianattasio KZ, Zhang Y, Walker RL, Crane PK, Larson E, Gibbons LE, Kumar RG, Dams-O’Connor K. Association of military employment with late life cognitive decline and dementia: a population-based prospective cohort study. Military Medicine. 2023;188(5-6):e1132-e1139. PMID: 34626181. PMCID:


81. Lee CS, Gibbons LE, Lee AY, Yanagihara RT, Blazes M, Lee ML, McCurry SM, Bowen JD, McCormick WC, Crane PK*, Larson EB*. Protective associations between cataract extraction and development of dementia: a prospective cohort analysis. JAMA Internal Medicine. 2022 Feb 1;182(2):134-141. doi: 10.1001/jamainternmed.2021.6990. * denotes co-senior author. PMID: 34870676 PMCID: PMC8649913.


82. Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi S-E, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Saucedo HH, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang H-S , Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team,. Pericak-Vance MA, Farrer LA, Wang L-S, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, and Hohman TJ. Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease. Brain 2022 Jul 29;145(7):2541-2554. doi: 10.1093/brain/awac177. PMID: 35552371. PMCID: PMC9337804.


83. Scollard P, Choi S-E, Lee ML, Mukherjee S, Trittschuh EH, Sanders RE, Gibbons LE, Joshi P, Devine S, Au R, Dams-O’Connor K, Saykin AJ, Seshadri S, Beiser A, Aparicio HJ, Salinas J, Gonzales MM, Pase MP, Ghosh S, Finney R, Mez J, Crane PK. Ceiling effects and differential measurement precision across calibrated cognitive scores in the Framingham study. Neuropsychology. 2023;37(4):383-397. PMCID: PMC10247160.


84. Hampton OL, Mukherjee S, Properzi MJ, Schultz AP, Crane PK, Gibbons LE, Hohman TJ, Maruff P, Lim YY, Amariglio RE, Papp KV, Johnson KA, Rentz DM, Sperling RA, Buckley RF. Harmonizing the Preclinical Alzheimer Cognitive Composite for multi-cohort studies. Neuropsychology 2023;37(4):436-449.. PMID: 35862098. PMCID: PMC9859944.


85. Mukherjee S, Choi S.-E., Lee M, Scollard P, Trittschuh EH, Mez J, Saykin AJ, Gibbons LE, Sanders RE, Zaman AF, Teylan MA, Kukull WA, Barnes LL, Bennett DA, Lacroix A, Larson EB, Cuccaro M, Mercado S, Dumitrescu L, Hohman TJ, Investigators from ACT, ADNI, ROS, MAP, MARS, NACC, and Crane PK. Cognitive domain harmonization and co-calibration in studies of older adults. Neuropsychology, 2023;37(4):409-423. PMCID: PMC9898463


86. Smith JR, Gibbons LE, Crane PK, Mungas DM, Glymour MM, Manly JJ, Zahodne LB, Mayeda ER, Jones RN, Gross AL. Shifting of cognitive assessments between face-to-face and telephone administration: measurement considerations. Journals of Gerontology Series B. Psychological Sciences. 2023;78(2):191-200. PMCID: PMC9938920.


87. Power MC, Parthasarathy V, Gianattasio KZ, Walker RL, Crane PK, Larson EB, Gibbons LE, Kumar RG, Dams-O’Connor K. Investigation of the association of military employment and Parkinson’s disease with a validated Parkinson’s disease case-finding strategy. Brain Injury. 2023;37(5):383-387. PMCID: PMC10033361.


88. Scaduto P, Lauterborn JC, Zeppillo T, Cox CD, Gutierrez BA, Keene CD, Crane PK, Mukherjee S, Russell WK, Limon A. Excitatory to inhibitory imbalance and loss of cognitive performance in people with Alzheimer’s disease neuropathologic change. Acta Neuropathologica. 2023;145(3):303-324. PMCID: PMC9925531


89. Crane PK, Choi S-E, Lee M, Scollard P, Sanders RE, Klinedinst B, Nakano C, Trittschuh EH, Mez J, Saykin AJ, Gibbons LE, Wang C, Mungas D, Zhu R, Foldi NS, Lamar M, Jutten R, Sikkes SAM, Grandoit E, Rabin LA, Jones RN, Tommet D, for the Alzheimer’s Disease Neuroimaging Initiative, Mukherjee S. Measurement precision across cognitive domains in the Alzheimer’s Disease Neuroimaging (ADNI) dataset. Neuropsychology. 2023;37(4):373-382. PMCID: PMC10247161.


90. Gibbons LE, Power MC, Walker RL, Kumar RG, Murphy A, Latimer CS, Nolan AL, Melief EJ, Beller A, Bogdana M, Keene CD, Larson EB, Crane PK, Dams-O’Connor K. Association of traumatic Brain Injury with late life neuropathological outcomes in a community-based cohort. Journal of Alzheimer’s Disease 2023;93(3):949-961. PMCID:


91. Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi S-E, Klinedinst B, Nakano C, Dumitrescu LC, Durant A, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang L-S, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KP, Mezx JB, Farrer LA. A genome-wise search for pleotropy in more than 100,000 harmoized longitudinal cognitive domain scores. Molecular Neurodegeneration 2023; 18: 40. https://doi.org/10.1186/s13024-023-00633-4.


92. Archer DB, Eissman JM, Mukherjee S, Lee ML, Choi S, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Gifford KA, The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), The Alzheimer’s Disease Sequencing Project (ADSP), Cuccaro ML, Pericak-Vance MA, Farrer LA, Wang L, Schellenberg GD, Mayeux RP, Haines JL, Jefferson AL, Kukull WA, Keene C, Saykin AJ, Thompson PA, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Dumitrescu L, Hohman TJ. Longitudinal change in memory performance as a strong endophenotype for Alzheimer’s disease. Alzheimer’s & Dementia. In press August 2023.


93. Eissman JM, Archer DB, Mukherjee S, Lee ML, Choi S-E, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Gifford KA, The Alzheimer’s Disease Neuroimaging Initiative (ADNI) Alzheimer’s Disease Genetics Consortium (ADGC), The Alzheimer’s Disease Sequencing Project (ADSP), Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang L-S, Schellenberg GD, Mayeux RP, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L (2023). Sex-specific genetic architecture of late-life memory performance. Alzheimer’s & Dementia. In press September 2023.


94. Cholerton B, Latimer CS, Crane PK, Corrada MM, Gibbons LE, Larson EB, Kawas C, Keene CD, Montine TJ. Neuropathologic burden and dementia in nonagenarians and centenarians: Comparison of two community-based cohorts. Neurology in press October 2023.


95. Crane PK, Groot C, Ossenkoppele R, Mukherjee S, Choi S-E, Lee M, Scollard P, Gibbons LE, Sanders RE, Trittschuh E, Saykin AJ, Mez J, Nakano C, Mac Donald C, Sohi H, for the Alzheimer's Disease Neuroimaging Initiative, Risacher S. Cognitively-defined Alzheimer’s dementia subgroups have distinct atrophy patterns. Alzheimer’s & Dementia. In press November 2023.


Published books, videos, software, etc.


1. Gibbons L, Jones RN, Crane P. runparscale (software for analyzing items and running Parscale within STATA). http://ideas.repec.org/c/boc/bocode/s456724.html (posted 2/2006)


2. Crane P, Gibbons L, Jolley L, van Belle G. difwithpar (differential item functioning software for STATA). http://ideas.repec.org/c/boc/bocode/s456722.html (posted 6/2006)


3. Gibbons L, Crane P. prepar (software for analyzing items and writing Parscale code for STATA). http://ideas.repec.org/c/boc/bocode/s456723.html (posted 6/2006)


4. Choi SW, with contributions from Gibbons LE, Crane PK. “lordif: logistic regression differential item functioning using IRT” (differential item functioning software for R). http://cran.r-project.org/web/packages/lordif/index.html (posted 11/2009)


Published abstracts and poster presentations


1. Crane PK, Freedland KE, Burroughs TE, Lustman PJ. Toward the development of a shortened form of the Beck Depression Inventory for monitoring changes in depression. Diabetes 2001; 50 Supplement 2: A389.


2. Crane P, van Belle G, Larson E. Utility of item response theory for predicting item sensitivity to change over time: data from two large ongoing studies of cognitive function in older adults. Neurobiology of Aging 2002; 23 (No. 1S): S36.


3. Arterburn DE, Crane PK, Veenstra DL. The efficacy and safety of sibutramine for weight loss: a systematic review. Journal of General Internal Medicine 2003; 18 Supplement 1: 140.


4. Arterburn DE, Crane PK, Sullivan SD. The coming epidemic of obesity in elderly Americans. Journal of General Internal Medicine 2003; 18 Supplement 1: 140.


5. Crane PK, Breitner JC, Psaty B, Kukull WA, Larson EB. Designing a study on the relationship between hormone replacement therapy and Alzheimer's disease risk: a methodological review with lessons from cardiovascular epidemiology. Journal of General Internal Medicine 2003; 18 Suppl 1: 193.


6. Crane PK, van Belle G, Jolley L, Gibbons L, Breitner JCS, Deyo R, Larson EB. A strategy for improving psychometric screening tests with tools from item response theory: theory and a brief illustration. Journal of Clinical Epidemiology 2003; 56: 920.


7. Crane PK, Gibbons LB, Lai J-S, Cella D. “Rapid detection of differential item functioning (DIF) in assessments of health related quality of life (HRQL): the Functional Assessment of Cancer Therapy (FACT).” Quality of Life Research 2005; 14: 2013.


8. Crane PK, Gibbons LE, Haneuse S, van Belle G, Erosheva E, Larson EB, Mungas DM. Accounting for measurement precision in a simulated longitudinal study of cognitive functioning dramatically improved the accuracy of estimates of the rate of change. Alzheimer’s and Dementia 2006; 2: Suppl 1, S302-303.


9. Nguyen VQ, Crane PK, Gibbons LE, Narasimhalu K, Arani K, McCurry SM, Rhoads K, Borenstein AR, Larson EB. The association between acculturation to Western society and decreased risk for incident Alzheimer’s disease is due to education and income differences in elderly Japanese Americans: the Kame Project. Alzheimer’s and Dementia 2006; 2: Suppl 1, S171.


10. Gibbons LE, Crane P, Narasimhalu K, Pedraza O, Mehta K, Tang Y, Manley J, Teresi J, Jones RN, Mungas DM. “The importance of education in accounting for differential item functioning related to language for an object naming test.” Alzheimer’s and Dementia 2006; 2: Suppl 1, S391.


11. Crane P, Gibbons LE, Narasimhalu K, Pedraza O, Mehta K, Tang Y, Manly JJ, Jones RN, Mungas DM. Accounting for differential item functioning in a measure of executive functioning improved the relationship with neuroimaging compared to standard scores. Alzheimer’s and Dementia 2006; 2: Suppl 1, S394-395.


12. Crane P, Gibbons LE, Arani K, Nguyen VQ, Rhoads K, McCurry S, Launer L, Masaki K, White L. Midlife proficiency with written Japanese and late life dementia risk among Japanese-American men: the Honolulu-Asia Aging Study. Alzheimer’s & Dementia 2007; 3: Suppl 2, S167.


13. Crane PK, McCurry SM, Gibbons LE, Larson EB, Feeney MP, Gates G. Item response theory-based composite executive functioning scores were more strongly correlated with dementia status than classical test theory-based composite executive functioning scores. Alzheimer’s & Dementia 2008; 4: 4 Suppl 2, T553.


14. Gibbons LE, McCurry SM, Rhoads K, Launer L, Masaki K, White L, Borenstein AR, Larson EB, Crane PK. Assessment of Japanese- and English-language equivalence of the Cognitive Abilities Screening Instrument (CASI) among Japanese-Americans in two large epidemiological studies. Alzheimer’s & Dementia 2008; 4: 4 Suppl 2, T559.


15. Gruhl J, Crane PK, Gibbons LE, Erosheva E, McCurry SM, Rhoads K, Nguyen VQ, Arani K, Launer LJ, Masaki K, White L. Self-reported use of written Japanese in midlife was not protective for late-life cognitive decline: the Honolulu-Asia Aging Study. Alzheimer’s & Dementia 2008; 4: 4 Suppl 2, T704.


16. Sonnen JA, Larson EB, Walker R, Haneuse S Crane PK, Gray SL, Breitner JCS, Montine TJ. Non-steroidal anti-inflammatory drugs are associated with increased neuritic plaques. Alzheimer’s & Dementia 2010; 6 (4) Suppl 1. S83.


17. Mukherjee S, Gibbons LE, Kristjansson E, Crane PK. Accounting for differential item functioning (DIF) in groups defined by educational attainment reduced the difference in rates of cognitive decline: illustration of a novel DIF detection framework using Modified Mini-Mental State Examination (3MS) data from the Canadian Study on Health and Aging (CSHA). Alzheimer’s & Dementia 2010; 6 (4) Suppl 1. S469-S470.


18. Mukherjee S, Gibbons LE, Kristjansson E, Crane PK. The relationship between educational attainment and the rate of cognitive decline in elderly Canadians depends on how one scores the 3MS: The Canadian study of health and aging (CSHA). Alzheimer’s & Dementia 2011; 7 (4) Suppl. S603.


19. Gibbons LE, Carle A, Insel P, Mackin S, Mukherjee S, Curtis SM, Harvey D, Mungas D, Weiner M, Crane PK. Composite scores for memory outperformed other approaches to the neuropsychological data collected by the Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimer's & Dementia 2011; 7 (4) Suppl. S245-S246.


20. Li G, Larson E, Shofer J, Crane P, Gibbons L, McCormick W, Bowen J, Thompson ML. Trajectory change of global cognitive function prior to dementia diagnosis. Alzheimer’s & Dementia 2012; 8(4) Supplement, p. P357.


21. Mukherjee S, Thornton T, Naj A, Kim S, Kauwe J, Fardo D, Valladares O, Wijsman E, Schellenberg G, Crane P. GWAS of the joint ADGC data set identifies novel common variants associated with late-onset Alzheimer’s disease. Alzheimer’s & Dementia 2013; 9(4) Supplement, p. P550.


22. Bekris L, Tsuang D, Leverenz J, Yu C-E, Lopez O, Hamilton R, Bennett D, Larson E, Crane P, Kaye J, Trojanowski J, Buchman A, Kramer P, Woltjer R, Schneider J, Weintraub D, Chen-Plotkin A, Nelson P, Jicha G, Schellenberg G, Kukull W, Watson S, Galasko D, Masliah E, Quinn J, Chung K, Yearout D, Mata I, Edwards K, Montine T, Zabetian C. A TOMM40 SNP in APO-ε4 noncarriers increases risk for multiple types of dementia. Alzheimer’s & Dementia 2013; 9(4) Supplement, p. P555.


23. Trittschuh E, Mukherjee S, Thornton T, Fardo D, Waterston L, Crane P, Mez J, Sherva R, Kauwe J, Naj A, Beecham G, Gross A, Saykin A, Green R. Genome-wide SNP analysis finds executive-prominent late-onset Alzheimer’s disease is highly heritable. Alzheimer’s & Dementia 2013; 9 (4) Supplement, p. P550-P551.


24. Ridge P, Mukherjee S, Crane P, Kauwe J, the Alzheimer’s Disease Genetics Consortium. Alzheimer’s disease: finding the missing heritability. Alzheimer’s & Dementia 2013; 9(4) Supplement p. P553-P554.


25. Chibnik L, Yu L, Raj T, Xu J, Patsopoulos N, Keenan B, Sherva R, Leurgans S, Blacker D, Wilson R, Reiman E, Huentelman M, The Alzheimer's Disease Genetics Consortium, Green R, Farrer L, Crane P, Weir D, Mayeux R, Lipton R, Schellenberg G, Evans D, De Jager P, Bennett D. Genome-wide association study for cognitive decline. Alzheimer’s & Dementia 2013; 9 (4) Supplement, p. P559-P560.


26. Gross A, Sherva R, Mukherjee S, Newhouse S, Waterston L, Zavitz K, Bennett D, Jones R, Crane P, Green R, Alzheimer’s Disease Neuroimaging Initiative (ADNI), GENAROAD Consortium. Calibration of a new approach for estimating general cognitive performance for GWAS of cognitive decline in Alzheimer’s disease. Alzheimer’s & Dementia 2013; 9 (4) Supplement; p. P697-P698.


27. Reitz C, Jun G, Naj A, Vardarajan B, Wang L-S, Larson E, Graff-Radford N, Evans D, De Jager P, Crane P, Buxbaum J, Ertekin-Taner N, Logue M, Green R, Cantwell L, Fallin D, Manly J, Lunetta K, Kamboh I, Lopez O, Bennett D, Hall KS, Goate A, Byrd G, Kukull W, Foroud T, Haines J, Farrer L, Pericak-Vance M, Schellenberg G, Mayeux R. Association or TREM2 variants with Alzheimer’s disease in African Americans: for the Alzheimer’s Disease Genetics Consortium. Alzheimer’s & Dementia 2013; 9 (4) Supplement, p. P175.


28. Choi SH, Reitz C, Chouraki V, Mukherjee S, Yu L, Ikram M, Bis J, Ibrahim-Verbaas C, de Bruijn R, Vardarajan B, Fitzpatrick A, Lopez O, Launer L, Grenier-Bolay B, Larson E, Bellenguez C, Lambert J-C, Mayeux R, Van Duijn C, Crane P, Seshadri S, Amouyel P, Destefano A, Bennett D. Genetic variants associated with incidence of late-onset Alzheimer’s disease in Caucasians. Alzheimer’s & Dementia 2013; 9 (4) Supplement; p. P176.


29. Nance RM, Drozd DR, Delaney JAC, Hecbert SR, Budoff MJ, Paramsothy P, Grunfeld C, Burkholder G, Willig JH, Mugavero MJ, Mathews WC, Rodriguez C, Moore RD, Eron JJ, Napravnik S, Crane PK, Hunt P, Hsue P, Lober WB, Kitahata MM, Saag MS, Crane HM, for the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) Cohort. Comparing cardiovascular disease risk scores for adjudication of events among HIV-infected patients in the CNICS Cohort. Infectious Disease Society of America (IDSA) Annual Meeting 2013.


30. Gray SL, Anderson ML, Dublin S, Hanlon J, Yu O, Walker R, Hubbard R, Crane P, Larson EB. Anticholinergic use and incident dementia. American Geriatrics Society meeting 2014.


31. Chibnik LB, Yu L, Raj T, Xu J, Patsopoulos N, Keenan BT, Sherva R, Leurgans SE, Blacker D, Wilson RS, Reiman EM, Huentelman M, Alzheimer’s Disease Genetics Consortium, Green RC, Farrer LA, Crane P, Mayeux R, Lipton R, Schellenberg GD, Evans DA, De Jager PL, Bennett DA. Genome wide association study for cognitive decline. American Society for Human Genetics 2013.


32. Serva R, Gross AL, Mukherjee S, Newhouse S, Kauwe J, Saykin AJ, Bennett DA, Chibnik LB, DeJager P, Kraft P, Crane PK, Green RC, for ADNI, the ADGC, and GENAROAD. GWAS of rate of cognitive decline in six AD cohorts. Poster presented at the American Society for Human Genetics, 2013.


33. Gross AL, Sherva R, Mukherjee S, Newhouse S, Waterston LB, Mungas DM, Green RC, Jones RN, Crane PK, for ADNI and the GENAROAD Consortium. Novel Approach for Calibrating Longitudinal Cognitive Performance in Older Adults. Poster presented at the Gerontological Society of America (GSA) conference, New Orleans, LA, November 2013.


34. Gross AL, Sherva R, Mukherjee S, Newhouse S, Kauwe J, Saykin AJ, Bennett DA, Chibnik LB, DeJager P, Kraft P, Naj A, Crane PK, Green RC, for ADNI, ADGC, and GENAROAD Consortium. Genome-Wide Association Study of Rate of Cognitive Decline in Six Cohorts with Patients with Alzheimer's Disease. Poster presented at the Gerontological Society of America (GSA) conference, New Orleans, LA, November 2013.


35. Gross AL, Mungas DM, Bennett DA, Carlson MC, Crane PK, Green RC, Manly JJ, Mukherjee S, Newhouse S, Parisi JM, Potter GG, Rebok GW, Romero H, Jones RN. Big questions in cognitive aging using big data: annual rates of cognitive decline in community-living older adults. Cognitive Aging Conference, Atlanta, GA, April 2014.


36. Mukherjee S, Postupna N, Keene CD, Larson EB, Montine TJ, Crane PK. Genome-wide analysis of amyloid beta (Abeta) peptide obtained from histelide identifies suggestive hits in RHBDF1, GRID1 and PTPRD regions in the Adult Changes in Thought (ACT) study. Poster presented at the Alzheimer's Association International Conference, July 2014, Copenhagen, DE.


37. Gross AL, Sherva R, Mukherjee S, Newhouse SJ, Waterston L, Green RC, Jones RN, Crane PK, for the Alzheimer’s Disease Neuroimaging Initiative and GENAROAD Consortium: Calibrating Longitudinal Cognitive Performance Across Diverse Neuropsychological Batteries and Datasets. Postr presented at the Alzheimer's Association International Conference, July 2014, Copenhagen, DE.


38. Chibnik LB, White CC, Raj T, Mukherjee S, Montgine TJ, Shulman J, Crane PK, Bennett DA, De Jager P. A novel susceptibility locus for neurofibrillary tangles at PTPRD: Evidence of pleiotropic effects on other brain pathologies. Poster presented at the Alzheimer's Association International Conference, July 2014, Copenhagen, DE.


39. LaCroix AZ, Hubbard R, Gray SL, Crane PK, Anderson M, Sonnen J, Larson EB, for the ACT Study Investigators. Trajectories of physical function prior to death and neuropathology in the Adult Changes in Thought (ACT) Autopsy Cohort. Poster presented at the Alzheimer's Association International Conference, July 2014, Copenhagen, DE.


40. Sonnen JA, Walker R, Gray SL, Crane PK, Montine TJ, Larson EB, for the ACT Study Investigators. Associations between cardioprotective doses of aspirin and age-related dementia and neuropathology in the Adult Changes in Thought (ACT) study. Poster presented at the Alzheimer's Association International Conference, July 2014, Copenhagen, DE.


41. Postupna NO, Hewitt JL, Sonnen JA, Larson EB, Crane PK, Keene CD, Montine TJ. Cortical burden of amyloid beta and PHF tau in demented and non-demented individuals. Poster presented at the Alzheimer's Association International Conference, July 2014, Copenhagen, DE.


42. R Fredericksen, A Church, L Smith, S Brown, JAC Delaney, R Nance, J Simoni, J Merrill, RD Harrington, S Dhanireddy, PK Crane, MM Kitahata, HM Crane. Factors associated with intentional inadequate adherence to antiretroviral therapy (ART) among PLWH. 10th International Conference on HIV Treatment and Prevention Adherence. Miami, 2015.


43. Risacher S, Kim S, Nho K, Shen L, Crane P, Aisen P, Petersen R, Jack C, Weiner M, Saykin A. Anticholinergic medication use in older adults is associated with memory and hippocampal volume. Alzheimer’s Association International Conference poster, Washington, D.C., July 18, 2015.


44. Risacher S, Shen L, West J, Zheng Y, Kim S, Nho K, Crane P, Aisen P, Petersen R, Jack C, Weiner M, Saykin A. Effect of hypertension and antihypertensive medication on executive function, brain atrophy, and white matter hyperintensities. Alzheiemr’s Association International Conference poster, Washington, D.C., July 18, 2015.


45. Bettcher B, Ard C, Reed B, Benitez A, Simmons A, Larson E, Sonnen J, Montine T, Li G, Crane P, Mungas D. Association between cholesterol exposure and neuropathological findings: the Adult Changes in Thought study. Alzheimer’s Association International Conference poster, Washington, D.C., July 18, 2015.


46. Del-Aguila J, Gross A, Sutti S, Sherva R, Mukherjee S, Crane P, Goate A, Morris J, Green R, Cruchaga C. Identification of genetic variants associated with Alzheimer’s disease progression rate. Alzheimer’s Association International Conference poster, Washington, D.C., July 18, 2015.


47. Mukherjee S, Gibbons L, Mac Donald C, Keene C, Montine T, Larson E, Crane P. Genome-wide association study of the robust aging in Adult Changes in Thought (ACT). Alzheimer’s Association International Conference poster, Washington, D.C., July 18, 2015.


48. Crane PK, Gross AL, Gibbons LE, Mez J, Trittschuh E, Mukherjee S, Saykin AJ, McCurry SM, McCormick W, Bowen JD, Kukul WA, Larson EB. Incidence of dementa subtypes in a community-based prospective cohort study: the Adult Changes in Thought (ACT) study. Alzheiemer’s Association International Conference poster, Toronto, Canada, July 24, 2016.


49. Mez J, Marden JR, Mukherjee S, Brewster P, Hamilton JL, Gilsanz P, Zahodne LB, Gross AL, Gibbons LE, Crane PK, Larson EB, Glymour MM. Alzheimer’s disease genetic risk variants beyond APOE4 predict mortality in the Adult Changes in Thought Study. Alzheiemer’s Association International Conference poster, Toronto, Canada, July 25, 2016.


50. Fardo DW, Gibbons LE, Mukherjee S, Glymour MM, McCormick W, McCurry SM, Bowen JD, Larson EB, Crane PK. Impact of home visit capacity on genetic association studies of late-onset Alzheimer’s disease. Alzheimer’s Association International Conference poster, Toronto, Canada, July 25, 2016.


51. Ridge P, Ebbert M, Hoyt K, Boehme KL, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe J. Assessment of the genetic variance of late-onset Alzheimer’s disease. Alzheiemer’s Association International Conference poster, Toronto, Canada, July 26, 2016.


52. Aiello Bowles EJ, Walker RL, Anderson ML, Dublin S, Crane PK, Larson E. Risk of Alzheimer’s disease following a cancer diagnosis. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P516.


53. Borenstein AR, Mortimer JA, Mbah A, Crane PK, Larson EB. Identification of latent reserve risk factors for dementia in two large prospective studies: confirmatory factor analysis. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P1178.


54. Mortimer JA, Borenstein AR, Mbah A, Crane PK, Larson EB. Role of reserve in reducing dementia: comparison of two large clinicopathologic studies. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P1183.


55. Aiello Bowles EJ, Walker RL, Crane PK, Keene CD, Chubak J, Anderson ML, LaCroix AZ, Larson EB. How do we measure resilience to brain aging, dementia, and Alzheimer’s disease. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P854.


56. Crane PK, Foroud TM, Montine TJ, Larson EB. Alzheimer’s disease sequencing project discovery and replication criteria for cases and controls: data from a community-based prospective cohort study with autopsy follow-up. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P971-972.


57. Hart LA, Marcum Z, Gray SL, Walker RL, Crane PK, Larson EB. Evaluating the association between central nervous system (CNS)-active medication use and fall-related injuries in older adults with dementia. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P1564-1565.


58. Bauman JR, Moore MR, Gibbons LE, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Glymour M, Mez J, Saykin AJ, Larson EB, Crane PK, for the Executive Prominent AD (EPAD) Investigators. Heterogeneity of risk across non-vascular risk factors for specific cognitively-defined Alzheimer’s disease subgroups. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P339-P340.


59. Moore MR, Gibbons LE, Bauman JR, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Mez J, Saykin AJ, Glymour M, Larson EB, Crane PK. Differential vascular risk factors for cognitively defined Alzheimer’s disease subgroups. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P517-P519.


60. Carr JS, Steele NZR, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Hoehme KL, Mukherjee S, Crane PK, Kauwe J, Kramer J, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS, for the Alzheimer’s Disease Neuroimaging Initiative. Fine-mapping of the human leukocyte antigen (HLA) locus as a risk factor for Alzheimer’s disease. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P652.


61. Lee CS, Gibbons LE, Lee AY, Bowen JD, McCormick W, McCurry SM, Larson EB, Crane PK. Ophthalmology-based AD risk factors: glaucoma, age-related macular degeneration, and diabetic retinopathy are each associatied with AD risk in a community-based cohort study. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P1488-P1489.


62. Mukherjee S, Mez J, Trittschuh E, Saykin AJ, Gibbons LE, Sanders RE, Fardo DW, Wessels M, Bauman J, Moore MR, Choi S-E, Gross AL, Grabowski TJ, Bird TD, Snitz BE, Kamboh MI, Bennett DA, Larson EB, Crane PK, for the EPAD Study Group and Investigators from ACT, ROS, MAP, ADNI, and the University of Pittsburgh ADRC. Psychometrically-defined late-onset Alzheimer’s disease (LOAD) subgroups in 5 studies (total n=4,170): prevalence at first visit, associations with APOE genotype and IGAP SNPs, and GWAS. Poster presentation, 2017 Alzheimer’s Association International Conference, London UK, July 2017. Published in Alzheimer’s & Dementia 2017; 13 (7) Supplement: p. P1488.


63. Wessels ME, Crane PK, Mez J, Trittschuh EH, Saykin AJ, Fardo DW, Thornton TA, Gibbons LE, Sanders RE, Mukherjee S, for the EPAD Study Group. Genome-wide analyses of isolated relative cognitive impairments identifies suggested hits in five studies. Poster presented at the 2018 Alzheimer’s Association International Conference, July 2018, Chicago, IL. Published in Alzheimer’s & Dementia 2018; 14(7) Supplement, p. P329.


64. Lee CS, Larson EB, Gibbons LE, Latimer CS, Keene D, Crane PK. Ophthalmology-based AD risk factors: diabetic retinopathy is associated with deep microinfarcts in a community-based autopsy study. Poster presented at the 2018 Alzheimer’s Association International Conference, July 2018, Chicago, IL. Published in Alzheimer’s & Dementia 2018; 14(7) Supplement, p. P520.


65. Mez J, Gibbons LE, Mukherjee S, Trittschuh EH, Fardo DW, Boyle P, Keene CD, Saykin AJ, Schneider JA, Crane PK. Longitudinal cognitive performance of Alzheimer’s disease neuropathological subtypes in the Religious Orders Study and the Memory and Aging Project. Poster presented at the 2018 Alzheimer’s Association International Conference, July 2018, Chicago, IL. Published in Alzheimer’s & Dementia 2018; 14(7) Supplement, p. P1592-P1593.


66. Burke BT, Latimer CS, Keene CD, Montine TJ, Sonnen J, McCormick W, Bowen JD, McCurrry SM, Larson EB, Crane PK. Autopsy findings of cerebral -amyloidosis, tauopathy, and neurodegeneration (A, T, and N) in a community-based sample: implications for dementia mitigation strategies. Poster presented at the 2018 Alzheimer’s Association International Conference, July 2018, Chicago, IL. Published in Alzheimer’s & Dementia 2018; 14(7) Supplement, p. P1593-1595.


67. Dumitrescu L, Deming Y, Lu Q, Beecham GW, Kunkle BW, Del-Aguila JL, Fernandez MV, Budde JP, Fagan AM, De Jager PL, Albert MS, Moghekar A, Riemenschneider M, Petersen RC, Barnes LL, Thambisetty M, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, Kukull WA, Crane PK, Resnick SM, Keene D, Montine TJ, Blennow K, Zetterberg J, Lennart M, Van Deerlin VM, Lee VM-Y, Shaw LM, Trojanowski JQ, Larson EB, Johnson SC, Schellenberg GD, Haines JL, Peskind ER, Li G, Cox NJ, Jefferson AL, Goate AM, Cruchaga C, Bennett DA, Schneider JA, Hohman TJ, for the Alzheimer’s Disease Genetics Consortium. The contribution of sex-specific associations in genetic studies of Alzheimer’s disease pathology. Poster presented at the 2018 Alzheimer’s Association International Conference, July 2018, Chicago, IL. Published in Alzheimer’s & Dementia 2018; 14(7) Supplement, p. P327-P328.


68. Groot C, Risacher SL, Chen JQA, Saykin AJ, Mac Donald C, Mez J, Trittschuh EH, Mukherjee S, Gibbons LE, Choi S-E, Sanders RE, Dicks E, Barkhof F, Scheltens P, van der Flier WM, Crane PK, Ossenkoppele R. FDG-PET Reveals Distinct Hypometabolic Trajectories in Cognitively-Defined Subgroups of Alzheimer’s Disease. Poster presented at the 2019 Alzheimer’s Association International Conference, July 2019, Los Angeles, CA. Published in Alzheimer’s & Dementia 2019; TBA.


69. Lee B, Crane PK, Risacher SL, Groot C, Mez J, Saykin AJ, Trittschuh E, Mac Donald C, Ossenkoppele R, Gibbons LE, Sanders RE, Choi S-E, Mukherjee S, Sohi H, Gennari J, Madhyastha T. Functional connectivity patterns across cognitively-defined Alzheimer’s disease subtypes in the Alzheimer’s Disease Neuroimaging Initiative. Poster presented at the 2019 Alzheimer’s Association International Conference, July 2019, Los Angeles, CA. Published in Alzheimer’s & Dementia 2019; TBA.


70. Crane PK Risacher SL, Groot C, Ossenkoppele R, Mez J, Saykin AJ, Trittschuh E, Mac Donald C, Gibbons le, Sanders RE, Choi S-E, Mukherjee S. Patterns of regional gray matter atrophy vary across cognitively-defined Alzheimer’s disease subgroups in ADNI. Poster presented at the 2019 Alzheimer’s Association International Conference, July 2019, Los Angeles, CA. Published in Alzheimer’s & Dementia 2019; TBA.


71. Sohi H, Gennari J, Madhyastha T, Lee BE, Risacher SL, Mac Donald C, Groot C, Ossnkoppele R, Mez J, Trittschuh EH, Saykin AJ, Mukherjee S, Gibbons LE, Sanders RE, Choi S-E, Crane PK. Regional differences in cortical thickness across cognitiuvely defined Alzheimer’s disease subgroups. Poster presented at the 2019 Alzheimer’s Association International Conference, July 2019, Los Angeles, CA. Published in Alzheimer’s & Dementia 2019; TBA.


72. Black GS, Boehme KL, Mukherjee S, Crane PK, Ridge PG, Kauwe J. Analyzing the SNP-based heritability in Alzheimer’s disease. Poster presented at the 2019 Alzheimer’s Association International Conference, July 2019, Los Angeles, CA. Published in Alzheimer’s & Dementia 2019; TBA.


73. Tremblay KL, Larson EB, Gibbons LE, Crane PK, Mohammed AB, Gates GA, Anderson ML, McCurry SM, Grabowski TJ. Central auditory dysfunction is a strong predictor of Alzheimer’s disease. Additional data from a prospective cohort study with extensive follow-up. Poster presented at the 2019 Alzheimer’s Association International Conference, July 2019, Los Angeles, CA. Published in Alzheimer’s & Dementia 2019; TBA.


74. Wessels ME, Crane PK, Mez J, Trittschuh EH, Saykin AJ, Mukherjee S. Genetic architecture of relative memory performance among people with Alzheimer’s disease differs by APOE genotype across five cohorts. Poster presented at the 2019 Alzheimer’s Association International Conference, July 2019, Los Angeles, CA. Published in Alzheimer’s & Dementia 2019; TBA.


75. Hu J, Chunbg J, Panitch R, Zhu C, Beecham GW, Mez J, Farrer LA, Stein TD, Crane PK, Jun GR. Defining Alzheimer’s disease subtypes using polygenic scores integrated wih genomic and brain transcriptomic profiles. Poster presented at the 2020 Alzheimer’s Association International Conference, July 2020, Virtual Conference. Published in Alzheimer’s & Dementia 2020; 16 (Suppl 2): e046449.


76. Moore MR, Chung J, Rosenthaler M, Uretsky M, Abdelmohammadi B, Raghavan NS, Farrell J, Bennett DA, Crane PK, Kamboh MI, Kukull WA, Larson EB, Haines JL, Pericak-Vance MA, Schellenberg GD, Mayeux R, Lunetta KL, Farrer LA, Mez J, Alzheimer’s Disease Genetics Consortium. Genome-wide interaction study of smking in Alzheimer’s disease. Poster presented at the 2020 Alzheimer’s Association International Conference, July 2020, Virtual Conference. Published in Alzheimer’s & Dementia 2020; 16 (Suppl 3): e046149.


77. Crane PK, Choi S-E, Gibbons LE, Mukherjee S, Zhu R, Scollard P, Lee ML, Trittschuh EH, Saykin AJ, Mez J, Mungas DM, Wang C, ADNI Psychometrics Investigators. Cognitive assessments in ADNI: Lessons learned from the ADNI Psychometrics project. Poster presented at the 2021 Alzheimer’s Association International Conference, July 2021, Denver, CO. Published in Alzheimer’s & Dementia 2021; 17 (Suppl 5): e056474.


78. Kang M, Mez JB, Ang TFA, Debvine SA, Mukherjee S, Trittschuh EH, Saykin AJ, Crane PK, Au R, Lunetta KL, Farrer LA. A genome-wide search for pleiotropy in cognitive domain scores. Poster presented at the 2022 Alzheimer’s Association International Conference, July 2022, San Diego, CA. Published in Alzheimer’s & Dementia 2022 18 (Suppl. 3): e066834.


79. Contreras AG, Walters S, Mukherjee S, Lee ML, Choi S-E, Scollard P, Trittschuh EH, Mez JB, Bush WS, Engelman CD, Lu Q, Fardo DW, Widaman KF, Buckley RF, Mormino EC, Kunkle BW, Naj AC, Clark LR, Gifford KA, Alzhemer's Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer's Disease Sequencing Project (ADSP), Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang L-S, Schellenberg GD, Haines HL, Jefferson AL, Johnson SC, Kukull WA, Albert MS, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L Sex differences in APOE effects on cognition are domain-specific. Poster presented at the 2022 Alzheimer’s Association International Conference, July 2022, San Diego, CA. Published in Alzheimer’s & Dementia 2022 18 (Suppl. 3): e068262.


80. Crane PK, Trittschuh EH, Mez JB, Saykin AJ, Sanders RE, Gibbons LE, Lee ML, Scollard P, Choi S-E, Rainey-Smith S, Chooi CK, Gavett BE, Maruff P, Ames D, Culhane JE, Gauthreaux K, Chan KCG, Biber S, Stephens K, Kukull WA, Dumitrescu L, Hohman TJ, Mukherjee S, Alzheimer’s Disease Neuroimaging Initiative. Development of harmonized and co-calibrated scores for memory executive functioning, language, and visuospatial in the AIBL Studym ADNI, and NACC datasets. Poster presented at the 2022 Alzheimer’s Association International Conference, July 2022, San Diego, CA. Published in Alzheimer’s & Dementia 2022 18 (Suppl. 11): e064534.


81. Kang K, Dumitrescu L, Mukherjee S, Lee ML, Choi S-E, Scollard P, Gibbons LE, Trittschuh EH, Mez JB, Saykin AJ, Gifford KA, Buckley RF, Crane PK, Hohman TJ, Gao X, Di J, Liu D, Alzheimer’s Disease Neuroimaging Initiative. Synchronized sigmoidal mixed-effects model for dynamics in cognitive decline relative to onset of Alzheimer’s disease in aging adults in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. Poster presented at the 2022 Alzheimer’s Association International Conference, July 2022, San Diego, CA. Published in Alzheimer’s & Dementia 2022 18 (Suppl. 11): e063496.


82. Yi D, Byun MS, Risacher SL, Craft H, Crane PK, Trittschuh EH, Mez JB, Choi S-E, Hohman TJ, Cuccaro ML, Lee ML, Scollard P, Gibbons LE, Mukherjee S, Nho K, Saykin AJ, Lee DY. The Korean brain aging study for the early diagnosis and prediction of Alzheimer’s disease (KBASE): cognitive data harmonization. Poster presented at the 2022 Alzheimer’s Association International Conference, July 2022, San Diego, CA. Published in Alzheimer’s & Dementia 2022 18 (Suppl. 8): e064533.


83. Mukherjee S, Ariza J, Gibbons LE, Rachleff VM, Travaglini KJ, Latimer CS, Melief EJ, Campos JS, Gabitto M, Miller JA, Ding Y, Levy B, Long B, Kaplan ES, Hodge RD, Larson EB, Crane PK, Lein ES, Keene SD, Seattle AD Brain Cell Atlas (SEA-AD). Rate of memory decline is associated with neuronal nuclear protein (NeuN) positive cells count in middle temporal gyrus in the Adult Changes in Thought (ACT) autopsy cohort. Poster presented at the 2022 Alzheimer’s Association International Conference, July 2022, San Diego, CA. Published in Alzheimer’s & Dementia 2022 18 (Suppl. 3): e063401.


84. Eissman JM, Smith AN, Mukherjee S, Lee ML, Choi S-E, Scollard P, Trittschuh EH, Mez JB, Bush WS, Engelman CD, Lu Q, Fardo DW, Widaman KF, Buckley RF, Mormino EC, Kunkle BW, Naj AC, Clark LR, Gifford KA, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Alzheimer's Disease Sequencing Project (ADSP), Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang L-S, Schellenberg GD, Haines JL, Jefferson AL, Johnson SC, Kukull WA, Albert MS, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L.Sex-specific genetic predictors of memory, executive functioning, and language performance. Poster presented at the 2022 Alzheimer’s Association International Conference, July 2022, San Diego, CA. Published in Alzheimer’s & Dementia 2022 18 (Suppl. 3): e067842.


85. Janve V, Archer D, Eissman J, Durant A, Mukherjee S, Lee M, Choi S-E, Scollard P, Trittschuh E, Mez J, Bush W, Engelman C, Lu Q, Fardo D, Buckley R, Mormino E, Kunkle B, Naj A, Gifford K, Cuccaro M, Cruchaga C, Pericak-Vance MA, Farrer L, Wang L-S, Schellenberg G, Haines J, Jefferson A, Kukull W, Alber MS, Keene CD, Saykin A, Sperling R, Mayeux R, Thompson P, Martin E, Bennett DA, Barnes L, Schneider J, Dumitrescu L, Crane P, Hohman A, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer’s Disease Sequencing Project (ADSP). Predicted gene expression identifies novel tissue-pseicifc gene predictors of memory performance in older adults. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


86. Rachleff VM, Ariza J, Bilgic K, Bogdani M, Campos JS, Close J, Crane PK, Ding Y, Gabitto MI, Grabowski TJ, Jayadev S, Keen A, Keene L, Khawand S, Larson EB, Latimer CS, Mac Donald C, Hawrylycz MJ, Kalpan ES, Long B, Melief EJ, Miller JA, Montine M, Mukherjee S, Nolan AL, Pacleb M, Postupna N, Schantz A, Staats B, Travaglini KJ, Wang M-Q, Wilson A, Lein ES, Keene CD. Large-scale quantitative neuropathological analysis across the spectrum of Alzheimer’s disease neuropathologic change. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; 19 (Suppl 1): e067844.


87. Miller JA, Hawrylycz MJ, Aitken M, Ariza J, Chakrabarty R, Ding S-L, Ding Y, Ferrer R, Goldy J, Gratly S, Guilford N, Guzman J, Kaplan ES, Mei N, Melief EJ, Nyhus J, Pham T, Rachleff VM, Samson J, Smith K, Torkelson A, Travaglini KJ, Wakeman W, Close J, Crane PK, Darvas M, Gabitto MI, Grabowski TJ, Hodge RD, Jayadev S, Latimer CS, Levi BP, Long B, Mac Donald C, Mukherjee S, Larson EB, Keene CD, Lein ES. SEA-AD: scientific analysis and open access resources targeting early changes in Alzheimer’s disease. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; 19 (Suppl. 8): e063478.


88. Scollard S, Mukherjee S, Choi S-E, Lee ML, Klinedinst BS, Gibbons LE, Trittschuh EH, Mez JB, Saykin AJ, James BD, Crane PK. Subgroups of Alzheimer’s disease determined by longitudinal change across three domains of cognition. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


89. Eissman JM, Walters S, Mukherjee S, Lee ML, Choi S-E, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj, AC, Gifford KA, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer's Disease Sequencing Project (ADSP), Alzheimer’s Disease Genetics Consortium (ADGC), Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang L-S, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Albert MS, Johnson SC, Engelman CD, Mayeux R, Vardarajan BN, Crane PK, Hohman TJ, Dumitrescu LC. Sex-specific genetic architecture of multiple domains of cognition among older adults. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


90. Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee ML, Choi S-E, Klinedinst BS, Nakano C, Dumitrescu LC, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang L-S, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg HD, Crane PK, Au R, Lunetta KL, Mex JB, Farrer LA. A genome-wide search for pleiotropy in more than 100,000 harmonized cognitive domain scores. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


91. Sinha S, Gibbons LE, Latimer CS, Crane PK, Keene CD, Mukherjee S. Development and assessment of a composite score for overall brain pathology in the Adult Changes in Thought (ACT) autopsy cohort. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


92. Walters S, Eissman JM, Mukherjee S, Lee ML, Choi S-E, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Gifford KA, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang L-S, Janes JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Albert MS, Johnson SC, Engelman CD, Mayeux R, Vadarajan BN, Hohman TJ, Dumitrescu LC, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer’s Disease Sequencing Project (ADSP). Genetic predictors of multiple cognitive domains within ancestry groups in older adults. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


93. Schwarze-Taufiq TA, Sammeth R, Crane PK, Gray SL, Young JE. Differential effects of anticholinergic medications in a human neuronal model of AD. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


94. Yang J-S, Mukherjee S, Latimer CS, Teng L, White CC, Yu L, Sperling RA, Larson EB, Crane PK, Keene CD, Bennett DA, Schneider JA, De Jager PL. A genbome-wide association study of LATE-NC (limbic predominant age-related TDP-43 encephalopathy neuropatholgic change) reveals a distinct genetic architecture. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


95. Lee ML, Scollard P, Gibbons LE, Mukherjee S, Choi S-E, Klinedinst BS, Trittschuh EH, Mez JB, Saykin AJ, Dumitrescu LC, Kukull WA, Hohman TJ, Crane PK. Relationships between neuroimaging parameters, APOE genotypes and composite scores for memory, executive functioning and language from the National Alzheimer’s Coordinating Center (NACC). Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


96. Contreras AG, Durant A, Mukherjee S, Lee ML, Choi S-E, Scollard P, Trittshuh EH, Mez JB, Bush WS, Engelman CD, Lu Q, Fardo DW, Widaman KF, Buckley R, Mormino EC, Kunkle BW, Naj AC, Clark LR, Gifford KA, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer’s Disease Sequencing Project (ADSP), Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang L-S, Schellenberg GD, Haines JL, Jefferson AL, Johnson SC, Kukull WA, Albert MS, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Dumitrescu LC, Hohman TJ. APOE4-stratified GWAS across cognitive domains in non-Hispanic whites and non-Hispanic black individuals. Poster presented at the 2023 Alzheimer’s Association International Conference, July 2023, Amsterdam, Netherlands. Published in Alzheimer’s & Dementia 2023; TBA.


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